The Rev. Billy Graham, a North Carolina farmer’s son who preached to millions in stadium events he called crusades, becoming a pastor to presidents and the nation’s best-known Christian evangelist for more than 60 years, died on Wednesday at his home in Montreat, N.C. He was 99.

His death was confirmed by Jeremy Blume, a spokesman for the Billy Graham Evangelistic Association.

Mr. Graham had dealt with a number of illnesses in his last years, including prostate cancer, hydrocephalus (a buildup of fluid in the brain) and symptoms of Parkinson’s disease.

Mr. Graham spread his influence across the country and around the world through a combination of religious conviction, commanding stage presence and shrewd use of radio, television and advanced communication technologies.

A central achievement was his encouraging evangelical Protestants to regain the social influence they had once wielded, reversing a retreat from public life that had begun when their efforts to challenge evolution theory were defeated in the Scopes trial in 1925.